Fatal reaction to acetazolamide.

Fatal reaction to acetazolamide.

ACETAZOLAMIDE is known to produce many minor side-effects when given for any length of time. Becker and Middleton (1955) have described the following in seventy patients receiving long-term acetazolamide for glaucoma: paresthesiae 61 per cent., gastrointestinal disturbances 49 per cent., excessive fatigue 16 per cent., urinary disturbances 4 per cent., hearing loss 3 per cent., leucopenia 3 per...

Fatal reaction to phenylbutazone in a patient with Reiter's disease.

Phenylbutazone was introduced into therapeutics in 1949: it rapidly became popular, and latterly, in Great Britain alone, general practitioners have been writing between 3 and 4 million prescriptions for it each year; quantities used in hospitals are unknown. Toxic effects include agranulocytosis, reactivation of peptic ulcers, rashes, vomiting, diarrhoea, and jaundice. The Dunlop Committee on ...

Fatal anaphylactoid reaction after primary exposure to aprotinin.

Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction ...

Fatal transfusion reaction due to the Kell factor.

Fatal acute systemic hypersensitivity reaction during haemodialysis.

Haemodialysis (HD)-associated anaphylactic and anaphylactoid reactions are found to be a complex problem, and though they have been well-documented in literature, a number of unexplored aspects remain. Anaphylaxis is a severe, life-threatening, generalized or systemic form of hypersensitivity. The clinical diagnosis is based on case history and physical examination, and includes symptoms of air...